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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Virological cure at day 5 15% Improvement Relative Risk HCQ for COVID-19  Shabrawishi et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 93 patients in Saudi Arabia No significant difference in viral clearance c19hcq.org Shabrawishi et al., medRxix, May 2020 Favors HCQ Favors control

Negative nasopharyngeal SARS-CoV-2 PCR conversion in response to different therapeutic interventions

Shabrawishi et al., medRxix, doi:10.1101/2020.05.08.20095679
May 2020  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 422 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,900+ studies for 60+ treatments. c19hcq.org
Retrospective 93 hospitalized patients in Saudi Arabia showing a non-statistically significant 15% reduction in PCR positive results at day 5, RR 0.85, p = 0.65. The treatment group had significantly more severe illness and significantly more male patients.
Although the viral clearance result is not statistically significant, it is consistent with the significant 19% improved viral clearance [10‑28%] from meta analysis of the 45 viral clearance results to date.
risk of no virological cure at day 5, 14.7% lower, RR 0.85, p = 0.66, treatment 12 of 45 (26.7%), control 15 of 48 (31.2%), NNT 22.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Shabrawishi et al., 11 May 2020, retrospective, Saudi Arabia, preprint, mean age 43.9, 5 authors.
This PaperHCQAll
Negative nasopharyngeal SARS-CoV-2 PCR conversion in Response to different therapeutic interventions
Mohammed Hassan Shabrawishi, Abdallah Y Naser, Hassan Alwafi, Ahmad Mansoor Aldobyany, Abdelfattah Ahmed Touman
doi:10.1101/2020.05.08.20095679
Take home message: Prescribing antimalarial medications for patients with COVID-19 was not shown to shorten the disease course nor to accelerate the negative PCR conversion rate.
CONFLICT OF INTEREST The authors have stated explicitly that there are no conflicts of interest in connection with this article. AUTHORS CONTRIBUTIONS Shabrawishi, Naser, Touman, and Alwafi had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Shabrawishi, and Touman had the original idea for this study. Shabrawishi, Naser, Touman, and Alwafi contributed to the design of the study. Shabrawishi and Touman contributed to the data collection. Naser
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For, Control, Information for Clinicians on Investigational Therapeutics for Patients with COVID-19 2020
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Magagnoli, Narendran, Pereira, Cummings, Hardin et al., Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19
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Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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