A New Model of SARS-CoV-2 Infection Based on (Hydroxy)Chloroquine Activity
, R., bioRxiv, doi:10.1101/2020.08.02.232892 (Preprint) (In Vitro)
In Vitro study presenting a new theory on SARS-CoV-2 infection and why HCQ/CQ provides benefits, which potentially explains the observed relationships with smoking, diabetes, obesity, age, and treatment delay, and confirms the importance of accurate dosing. Metabolic analysis revealed HCQ/CQ inhibit oxidative phosphorylation in mitochondria (likely by sequestering protons needed to drive ATP synthase), inhibiting infection and/or slowing replication.
Sheaff et al., 8/2/2020, preprint, 1 author.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
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