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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 47% Improvement Relative Risk c19hcq.com/signescosta.html Favors HCQ Favors control
16 December 2020 - Late treatment study
Prevalence and 30-day mortality in hospitalized patients with COVID-19 and prior lung diseases
Signes-Costa et al., Archivos de Bronconeumología, doi:10.1016/j.arbres.2020.11.012 (Peer Reviewed)
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47% lower mortality with HCQ/CQ. Retrospective 1,271 patients with lung disease in Canada, China, Cuba, Ecuador, Germany, Italy and Spain, 83% treated with HCQ/CQ.
Multivariable Cox regression HCQ/CQ mortality hazard ratio HR 0.53, p < 0.001.
risk of death, 47.0% lower, RR 0.53, p < 0.001, treatment 4,854, control 993, adjusted per study.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Signes-Costa et al., 12/16/2020, retrospective, multiple countries, multiple regions, peer-reviewed, 28 authors.
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