et al., New Microbes and New Infections, doi:10.1016/j.nmni.2020.100813 (Peer Reviewed)
100% reduction in cases with HCQ+zinc post-exposure prophylaxis. Brief report for healthcare workers in Bulgaria.
0 cases with treatment vs. 3 for control.
156 treatment patients and 48 control patients.
No serious adverse events. This paper reports on both PEP and early treatment, we have separated the two studies.
Simova et al., 11/12/2020, retrospective, Bulgaria, Europe, peer-reviewed, 5 authors.
risk of COVID-19 case, 92.7% lower, RR 0.07, p = 0.01, treatment 0 of 156 (0.0%), control 3 of 48 (6.2%).
Effect extraction follows pre-specified rules prioritizing more serious
outcomes. For an individual study the most serious outcome may have a smaller
number of events and lower statistical signficance, however this provides the
strongest evidence for the most serious outcomes when combining the results of