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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Severe case 90% Improvement Relative Risk Moderate/severe case -19% Moderate/severe case (b) 79% Case 60% c19vitamind.com/sinaci.html Favors vitamin D Favors control
11 August 2021 - Prophylaxis study
Impact of vitamin D on the course of COVID-19 during pregnancy: A case control study
Sinaci et al., The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2021.105964 (Peer Reviewed)
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Retrospective 159 COVID-19+ pregnant women in Turkey and 332 healthy pregnant controls, showing significantly lower vitamin D levels in COVID-19+ patients. 23% of COVID-19 patients where on vitamin D supplementation, while none of the 7 severe cases were on supplementation.
risk of severe case, 90.0% lower, RR 0.10, p = 0.35, treatment 0 of 36 (0.0%), control 7 of 123 (5.7%), NNT 18, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), supplementation.
risk of moderate/severe case, 18.8% higher, RR 1.19, p = 0.64, treatment 8 of 36 (22.2%), control 23 of 123 (18.7%), supplementation.
risk of moderate/severe case, 79.5% lower, RR 0.21, p < 0.001, high D levels (≥10ng/mL) 8 of 100 (8.0%), low D levels (<10ng/mL) 23 of 59 (39.0%), NNT 3.2, cutoff ≥10ng/mL.
risk of case, 59.9% lower, RR 0.40, p < 0.001, high D levels (≥10ng/mL) 100 of 397 (25.2%), low D levels (<10ng/mL) 59 of 94 (62.8%), NNT 2.7, cutoff ≥10ng/mL.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Sinaci et al., 8/11/2021, retrospective, Turkey, Europe, peer-reviewed, 10 authors, dosage not specified.
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