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0 0.5 1 1.5 2+ Case -9% Improvement Relative Risk c19hcq.com Singer et al. HCQ for COVID-19 PrEP Favors HCQ Favors control
Singer, 32,758 patient HCQ prophylaxis study: 9% more cases [p=0.62] https://c19p.org/singer
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Hydroxychloroquine ineffective for COVID-19 prophylaxis in lupus and rheumatoid arthritis
Singer et al., Annals of the Rheumatic Diseases, doi:10.1136/annrheumdis-2020-218500 (Letter)
5 Aug 2020    Source   PDF   Share   Tweet
Comparison of the percentage of SLE/RA patients on immunosuppressants that were taking HCQ, for COVID-19 diagnosis versus other infections or outpatient visits, finding a similar percentage in each case.
No mortality of severity information is provided to determine if HCQ treated patients fared better. No adjustment for concomitant medications or severity.
risk of case, 9.0% higher, RR 1.09, p = 0.62, treatment 55 of 10,700 (0.5%), control 104 of 22,058 (0.5%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: not fully adjusting for the baseline risk differences within systemic autoimmune patients.
Singer et al., 8/5/2020, retrospective, database analysis, USA, North America, preprint, 3 authors.
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