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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality -18% Improvement Relative Risk c19hcq.com/solh.html Favors HCQ Favors control
20 October 2020 - Late treatment study
Clinical course and outcome of COVID-19 acute respiratory distress syndrome: data from a national repository
Solh et al., medRxiv, doi:10.1101/2020.10.16.20214130 (Preprint)
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Retrospective database analysis of 7,816 Veterans Affairs hospitalized patients analyzing progression to ARDS and 30-day mortality from ARDS. Confounding by indication is likely. Chronological bias is likely, with HCQ more likely to be used earlier on, before significant improvements in overall treatment.
No results are provided for HCQ for progression to ARDS.
risk of death, 18.0% higher, RR 1.18, p = 0.17, treatment 131 of 265 (49.4%), control 134 of 378 (35.4%), adjusted per study.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
This study is excluded in the after exclusion results of meta analysis: very late stage, >50% on oxygen/ventilation at baseline, substantial unadjusted confounding by indication likely.
Solh et al., 10/20/2020, retrospective, database analysis, USA, North America, preprint, 5 authors.
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