Meta analysis of 11 HCQ PrEP studies in India covering 7,616 healthcare workers, showing significantly lower cases with treatment.
Stricker et al., 8/5/2021, peer-reviewed, 2 authors.
risk of death, 75.0% lower, RR 0.25, p < 0.001, treatment 1273, control 4127, >=6 doses.
risk of death, 44.0% lower, RR 0.56, p = 0.004, treatment 3489, control 4127, any number of doses.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.