Observational prospective 5,541 patients, adjusted HCQ mortality odds ratio OR 0.36, p
= 0.012. Adjusted hospitalization OR 0.57, p
< 0.001. Zinc supplementation was used in all cases. Early treatment in ambulatory fever clinics in Saudi Arabia.
Sulaiman et al., 9/13/2020, prospective, Saudi Arabia, Middle East, preprint, 22 authors, dosage 400mg bid day 1, 200mg bid days 2-5.
risk of death, 63.7% lower, RR 0.36, p = 0.01, treatment 7 of 1817 (0.4%), control 54 of 3724 (1.5%), adjusted per study, odds ratio converted to relative risk.
risk of hospitalization, 38.6% lower, RR 0.61, p = 0.001, treatment 171 of 1817 (9.4%), control 617 of 3724 (16.6%), adjusted per study, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.