The Effect of Early Hydroxychloroquine-based Therapy in COVID-19 Patients in Ambulatory Care Settings: A Nationwide Prospective Cohort Study

9/13 Early treatment study

Sulaiman et al., medRxiv, doi:10.1101/2020.09.09.20184143 (Preprint)
The Effect of Early Hydroxychloroquine-based Therapy in COVID-19 Patients in Ambulatory Care Settings: A Nationwide Prospective Cohort Study

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Observational prospective 5,541 patients, adjusted HCQ mortality odds ratio OR 0.36, p = 0.012. Adjusted hospitalization OR 0.57, p < 0.001. Zinc supplementation was used in all cases. Early treatment in ambulatory fever clinics in Saudi Arabia.

Sulaiman et al., 9/13/2020, prospective, Saudi Arabia, Middle East, preprint, 22 authors, dosage 400mg bid day 1, 200mg bid days 2-5.

risk of death, 63.7% lower, RR 0.36, p = 0.01, treatment 7 of 1817 (0.4%), control 54 of 3724 (1.5%), adjusted per study, odds ratio converted to relative risk.

risk of hospitalization, 38.6% lower, RR 0.61, p = 0.001, treatment 171 of 1817 (9.4%), control 617 of 3724 (16.6%), adjusted per study, odds ratio converted to relative risk.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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