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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Symptomatic case -60% Improvement Relative Risk Symptomatic case (b) -110% Symptomatic case (c) 16% Case -92% Case (b) -137% Case (c) -21% c19hcq.com/syed.html Favors HCQ Favors control
17 May 2021 - Pre-Exposure Prophylaxis study (treated before exposed to the virus)
Pre-exposure Prophylaxis With Various Doses of Hydroxychloroquine Among Healthcare Personnel With High-Risk Exposure to COVID-19: A Randomized Controlled Trial
Syed et al., Cureus, doi:10.7759/cureus.20572 (preprint 5/17/2021) (Peer Reviewed)
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Small PrEP RCT of low risk patients, showing no significant differences. Authors report that there was no hospitalization, ICU care, or death from COVID-19, however table 3 of the preprint shows severe events labeled as "requiring hospitalization". Symptomatology and disease severity results in tables 3 and 4 appear inconsistent. NCT04359537.
risk of symptomatic case, 59.7% higher, RR 1.60, p = 0.41, treatment 10 of 48 (20.8%), control 6 of 46 (13.0%), group 1.
risk of symptomatic case, 110.5% higher, RR 2.10, p = 0.13, treatment 14 of 51 (27.5%), control 6 of 46 (13.0%), group 2.
risk of symptomatic case, 16.4% lower, RR 0.84, p = 0.77, treatment 6 of 55 (10.9%), control 6 of 46 (13.0%), NNT 47, group 3.
risk of case, 91.7% higher, RR 1.92, p = 0.12, treatment 15 of 38 (39.5%), control 7 of 34 (20.6%), group 1.
risk of case, 136.6% higher, RR 2.37, p = 0.02, treatment 19 of 39 (48.7%), control 7 of 34 (20.6%), group 2.
risk of case, 21.4% higher, RR 1.21, p = 0.77, treatment 8 of 32 (25.0%), control 7 of 34 (20.6%), group 3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Syed et al., 5/17/2021, Randomized Controlled Trial, Pakistan, South Asia, peer-reviewed, 8 authors.
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