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0 0.5 1 1.5 2+ Symptomatic case -60% Improvement Relative Risk Symptomatic case (b) -110% Symptomatic case (c) 16% Case -92% Case (b) -137% Case (c) -21% c19hcq.com Syed et al. NCT04359537 HCQ RCT PrEP Favors HCQ Favors control
Syed, 101 patient HCQ prophylaxis RCT: 60% more symptomatic cases [p=0.41] and 92% more cases [p=0.12] https://c19p.org/syed
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Pre-exposure Prophylaxis With Various Doses of Hydroxychloroquine Among Healthcare Personnel With High-Risk Exposure to COVID-19: A Randomized Controlled Trial
Syed et al., Cureus, doi:10.7759/cureus.20572 (preprint 5/17/2021)
17 May 2021    Source   PDF   Share   Tweet
Small PrEP RCT of low risk healthcare workers, showing no significant differences. Authors report that there was no hospitalization, ICU care, or death from COVID-19, however table 3 of the preprint shows severe events labeled as "requiring hospitalization". Symptomatology and disease severity results in tables 3 and 4 appear inconsistent. NCT04359537.
risk of symptomatic case, 59.7% higher, RR 1.60, p = 0.41, treatment 10 of 48 (20.8%), control 6 of 46 (13.0%), group 1.
risk of symptomatic case, 110.5% higher, RR 2.10, p = 0.13, treatment 14 of 51 (27.5%), control 6 of 46 (13.0%), group 2.
risk of symptomatic case, 16.4% lower, RR 0.84, p = 0.77, treatment 6 of 55 (10.9%), control 6 of 46 (13.0%), NNT 47, group 3.
risk of case, 91.7% higher, RR 1.92, p = 0.12, treatment 15 of 38 (39.5%), control 7 of 34 (20.6%), group 1.
risk of case, 136.6% higher, RR 2.37, p = 0.02, treatment 19 of 39 (48.7%), control 7 of 34 (20.6%), group 2.
risk of case, 21.4% higher, RR 1.21, p = 0.77, treatment 8 of 32 (25.0%), control 7 of 34 (20.6%), group 3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Syed et al., 5/17/2021, Randomized Controlled Trial, Pakistan, South Asia, peer-reviewed, 8 authors, trial NCT04359537.
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