The Activin/Follistatin-axis is severely deregulated in COVID-19 and independently associated with in-hospital mortality

9/5 Late treatment study

Synolaki et al., medRxiv, doi:10.1101/2020.09.05.20184655 (Preprint)
The Activin/Follistatin-axis is severely deregulated in COVID-19 and independently associated with in-hospital mortality

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Retrospective 117 patients, 58 HCQ showing lower mortality for HCQ patients.

Version 1 of this paper stated: "HCQ, AZ, [and ...] were found to be independently associated with survival when treatment commenced at FACTCLINYCoD scores <3".

Synolaki et al., 9/5/2020, retrospective, Greece, Europe, preprint, 20 authors.

risk of death, 23.6% lower, RR 0.76, p = 0.27, treatment 21 of 98 (21.4%), control 60 of 214 (28.0%).

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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