Retrospective 1,747 ICU patients in Belgium showing lower mortality with HCQ, multivariate mixed effects analysis HCQ aOR 0.64 [0.45-0.92].
Taccone et al., 12/23/2020, retrospective, Belgium, Europe, peer-reviewed, 10 authors.
risk of death, 24.7% lower, RR 0.75, p < 0.001, treatment 449 of 1,308 (34.3%), control 183 of 439 (41.7%), odds ratio converted to relative risk.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.