Risk factors for mortality in adult COVID-19 patients: frailty predicts fatal outcome in older patients

10/30 Late treatment study

Tehrani et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2020.10.071 (Peer Reviewed)
Risk factors for mortality in adult COVID-19 patients: frailty predicts fatal outcome in older patients

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Retrospective 255 hospitalized patients, 65 treated with HCQ, showing unadjusted RR 0.87, p=0.63. Confounding by indication is likely.

Tehrani et al., 10/30/2020, retrospective, Sweden, Europe, peer-reviewed, 5 authors.

risk of death, 13.4% lower, RR 0.87, p = 0.63, treatment 16 of 65 (24.6%), control 54 of 190 (28.4%).

This study is excluded in meta analysis: substantial unadjusted confounding by indication likely, unadjusted results with no group details.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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