et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2020.10.071 (Peer Reviewed)
Retrospective 255 hospitalized patients, 65 treated with HCQ, showing unadjusted RR 0.87, p
=0.63. Confounding by indication is likely.
Tehrani et al., 10/30/2020, retrospective, Sweden, Europe, peer-reviewed, 5 authors.
risk of death, 13.4% lower, RR 0.87, p = 0.63, treatment 16 of 65 (24.6%), control 54 of 190 (28.4%).
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.