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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality -6% Improvement Relative Risk Mortality (b) -51% 7-point scale -3% 7-point scale (b) 2% c19hcq.com/thompson.html Favors HCQ Favors control
9 February 2021 - Late treatment study
Outcomes Related to COVID-19 Treated With Hydroxychloroquine Among In-patients With Symptomatic Disease (ORCHID)
Thompson et al., NCT04332991 (Preprint)
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Late stage (65% on oxygen at baseline) low-dose RCT, not showing significant differences with treatment.
risk of death, 6.2% higher, RR 1.06, p = 0.85, treatment 25 of 241 (10.4%), control 25 of 236 (10.6%), NNT 455, adjusted per study, odds ratio converted to relative risk, day 28.
risk of death, 51.0% higher, RR 1.51, p = 0.28, treatment 18 of 241 (7.5%), control 14 of 236 (5.9%), adjusted per study, odds ratio converted to relative risk, day 14.
risk of 7-point scale, 3.1% higher, RR 1.03, p = 0.87, treatment 241, control 236, day 28, RR approximated with OR.
risk of 7-point scale, 2.0% lower, RR 0.98, p = 0.91, treatment 241, control 236, day 14, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Thompson et al., 2/9/2021, Double Blind Randomized Controlled Trial, USA, North America, preprint, 1 author.
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