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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality -6% Improvement Relative Risk Mortality (b) -51% 7-point scale -3% 7-point scale (b) 2% c19hcq.com Thompson et al. HCQ for COVID-19 RCT LATE TREATMENT Favors HCQ Favors control
Thompson, 477 patient HCQ late treatment RCT: 6% higher mortality [p=0.85] and 3% worse 7-point scale results [p=0.87] https://c19p.org/thompson
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Outcomes Related to COVID-19 Treated With Hydroxychloroquine Among In-patients With Symptomatic Disease (ORCHID)
Thompson et al., NCT04332991 (Preprint)
9 Feb 2021    Source   PDF   Share   Tweet
Late stage (65% on oxygen at baseline) low-dose RCT, not showing significant differences with treatment.
risk of death, 6.2% higher, RR 1.06, p = 0.85, treatment 25 of 241 (10.4%), control 25 of 236 (10.6%), NNT 455, adjusted per study, odds ratio converted to relative risk, day 28.
risk of death, 51.0% higher, RR 1.51, p = 0.28, treatment 18 of 241 (7.5%), control 14 of 236 (5.9%), adjusted per study, odds ratio converted to relative risk, day 14.
risk of 7-point scale, 3.1% higher, OR 1.03, p = 0.87, treatment 241, control 236, day 28, RR approximated with OR.
risk of 7-point scale, 2.0% lower, OR 0.98, p = 0.91, treatment 241, control 236, day 14, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Thompson et al., 2/9/2021, Double Blind Randomized Controlled Trial, USA, North America, preprint, 1 author.
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Late treatment
is less effective
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