Outcomes Related to COVID-19 Treated With Hydroxychloroquine Among In-patients With Symptomatic Disease (ORCHID)

2/9 Late treatment study

Thompson et al., NCT04332991 (Preprint)
Outcomes Related to COVID-19 Treated With Hydroxychloroquine Among In-patients With Symptomatic Disease (ORCHID)

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Late stage (65% on oxygen at baseline) low-dose RCT, not showing significant differences with treatment.

Thompson et al., 2/9/2021, Double Blind Randomized Controlled Trial, USA, North America, preprint, 1 author.

risk of death, 6.2% higher, RR 1.06, p = 0.84, treatment 25 of 241 (10.4%), control 25 of 236 (10.6%), adjusted per study, odds ratio converted to relative risk, day 28.

risk of death, 51.0% higher, RR 1.51, p = 0.25, treatment 18 of 241 (7.5%), control 14 of 236 (5.9%), adjusted per study, odds ratio converted to relative risk, day 14.

risk of 7-point scale status, 3.1% higher, RR 1.03, p = 0.87, treatment 241, control 236, day 28.

risk of 7-point scale status, 2.0% lower, RR 0.98, p = 0.91, treatment 241, control 236, day 14.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

All 344 studies Meta Analysis

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