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0 0.5 1 1.5 2+ Mortality -17% Improvement Relative Risk Death/ICU -78% Hospitalization -45% c19hcq.com Trefond et al. HCQ for COVID-19 PrEP Favors HCQ Favors control
Trefond, 262 patient HCQ prophylaxis study: 17% higher mortality [p=0.8], 78% higher combined mortality/ICU admission [p=0.21], and 45% higher hospitalization [p=0.12] https://c19p.org/trefond
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Effet d’un traitement par hydroxychloroquine prescrit comme traitement de fond de rhumatismes inflammatoires chroniques ou maladies auto-immunes systémiques sur les tests diagnostiques et l’évolution de l’infection à SARS CoV-2: étude de 871 patients
Trefond et al., Revue du Rhumatisme, doi:10.1016/j.rhum.2021.09.004 (date from earlier preprint)
27 Jan 2021    Source   PDF   Share   Tweet
Retrospective 71 chronic HCQ patients compared with 191 matched controls, analyzing only those with a highly suspected or confirmed diagnosis of COVID-19. No significant difference was found in outcomes, however matching failed with extreme confounding - 77.5% of HCQ patients with systemic autoimmune diseases vs. 21.5% of control patients.
Other research shows that the risk of COVID-19 for systemic autoimmune disease patients is much higher overall, Ferri et al. show OR 4.42, p<0.001 [Ferri].
risk of death, 16.6% higher, RR 1.17, p = 0.80, treatment 4 of 68 (5.9%), control 12 of 183 (6.6%), adjusted per study, odds ratio converted to relative risk.
risk of death/ICU, 78.2% higher, RR 1.78, p = 0.21, treatment 8 of 71 (11.3%), control 18 of 191 (9.4%), adjusted per study, odds ratio converted to relative risk.
risk of hospitalization, 44.9% higher, RR 1.45, p = 0.12, treatment 24 of 71 (33.8%), control 53 of 191 (27.7%), adjusted per study, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: not fully adjusting for the different baseline risk of systemic autoimmune patients, significant unadjusted confounding possible, excessive unadjusted differences between groups.
Trefond et al., 27 Jan 2021, retrospective, France, peer-reviewed, 21 authors.
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