Retrospective 100 hospitalized patients in Spain showing lower mortality with HCQ+AZ.
Trullàs et al., 7/14/2020, retrospective, Spain, Europe, preprint, median age 75.0, 8 authors.
risk of death, 35.6% lower, RR 0.64, p = 0.12, treatment 20 of 66 (30.3%), control 16 of 34 (47.1%).
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.