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Remdesivir study #20 of 32   All Outcomes
3/10 Late treatment study
Tsuzuki et al., medRxiv, doi:10.1101/2021.03.09.21253183 (Preprint)
Efficacy of remdesivir in Japanese patients hospitalised with COVID-19: A large observational study using the COVID-19 Registry Japan
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Retrospective database analysis of 1907 hospitalized patients in Japan, using PSM to compare 74 remdesivir patients and 195 control patients, not showing significant differences in mortality and ventilation/ECMO, and showing signifcantly longer hospital stay with treatment. PSM did not fully match the patients, for example 65% of matched remdesivir patients were over 65, while only 55% of matched control patients were.
Tsuzuki et al., 3/10/2021, retrospective, propensity score matching, Japan, Asia, preprint, 20 authors.
risk of death, 8.8% lower, RR 0.91, p = 1.00, treatment 9 of 74 (12.2%), control 26 of 195 (13.3%), PSM.
risk of mechanical ventilation or ECMO, 17.1% higher, RR 1.17, p = 0.76, treatment 4 of 74 (5.4%), control 9 of 195 (4.6%), PSM.
hospitalization time, 27.3% higher, relative time 1.27, p < 0.001, treatment 74, control 195, PSM.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
All 32 studies   All Outcomes
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