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0 0.5 1 1.5 2+ Mortality -6% Improvement Relative Risk c19hcq.com Ulrich et al. HCQ for COVID-19 RCT LATE TREATMENT Favors HCQ Favors control
Ulrich, 128 patient HCQ late treatment RCT: 6% higher mortality [p=1] https://c19p.org/ulrich
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Treating Covid-19 With Hydroxychloroquine (TEACH): A Multicenter, Double-Blind, Randomized Controlled Trial in Hospitalized Patients
Ulrich et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofaa446
23 Sep 2020    Source   PDF   Share   Tweet
Small RCT on very late stage use of HCQ, with 48% on oxygen at baseline. 67 HCQ patients, 61 control.
Baseline states were not comparable - 82% more HCQ patients had the highest severity at baseline, there was 32% more male HCQ patients, and 44% more control patients used AZ. The HCQ group also had significantly more patients with cerebrovascular disease, cardiovascular disease (non-hypertension), renal disease (non-dialysis), and a history of organ transplants.
30 day mortality RR 1.06, p = 1.0.
risk of death, 6.0% higher, RR 1.06, p = 1.00, treatment 7 of 67 (10.4%), control 6 of 61 (9.8%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: very late stage, >50% on oxygen/ventilation at baseline.
Ulrich et al., 9/23/2020, Randomized Controlled Trial, USA, North America, peer-reviewed, baseline oxygen required 63.3%, mean age 66.2, 18 authors, average treatment delay 7.0 days.
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