Database analysis of 7,592 patients in NYC, showing adjusted HCQ mortality odds ratio OR 0.96,
p = 0.82, and HCQ+AZ OR 0.94,
p = 0.63
Wang et al., 6/10/2020, retrospective, database analysis, USA, North America, preprint, 3 authors.
risk of death, 5.8% lower, RR 0.94, p = 0.63, treatment 1866, control 5726, odds ratio converted to relative risk.
This study is excluded in meta analysis: confounding by indication is likely and adjustments do not consider COVID-19 severity.
Effect extraction follows
pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.