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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Case 42% Improvement Relative Risk c19hcq.com/wiseman2.html Favors HCQ Favors control
2 December 2020 - Post Exposure Prophylaxis study (treated after exposure to the virus)
Effective post-exposure prophylaxis of Covid-19 is associated with use of hydroxychloroquine: Prospective re-analysis of a public dataset incorporating novel data
Wiseman et al., medRxiv, doi:10.1101/2020.11.29.20235218 (Preprint) (meta analysis)
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6th independent analysis showing efficacy from the Boulware PEP trial. This prospective analysis corrects an error in the NEJM paper where shipping delays are omitted (still not corrected).
42% reduction in COVID-19 (9.6% vs. 16.5%), RR 0.58 [0.35 - 0.97], p=0.044, for the original trial 3 day specification.
risk of case, 42.0% lower, RR 0.58, p = 0.04, <= 3 days after exposure.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Wiseman et al., 12/2/2020, preprint, 4 authors.
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