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0 0.5 1 1.5 2+ Hospitalization 82% Improvement Relative Risk IgG+ 42% IgG+ (b) 79% IgG+ (c) 52% IgG+ (d) -70% c19hcq.com Yadav et al. HCQ for COVID-19 PrEP Favors HCQ Favors control
Yadav, 500 patient HCQ prophylaxis study: 82% lower hospitalization [p=0.01] and 42% fewer cases [p=0.05] https://c19p.org/yadav3
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Sero-survey for health-care workers provides corroborative evidence for the effectiveness of Hydroxychloroquine prophylaxis against COVID-19 infection
Yadav et al., ResearchGate, doi:10.13140/RG.2.2.34411.77603 (Preprint)
30 Sep 2020    Source   PDF   Share   Tweet
ICMR seroprevalence survey of 500 healthcare workers in India, 279 taking HCQ prophylaxis, showing a significantly lower risk with treatment, and lower severity.
risk of hospitalization, 82.4% lower, RR 0.18, p = 0.01, treatment 2 of 279 (0.7%), control 9 of 221 (4.1%), NNT 30, PCR+.
risk of IgG+, 41.8% lower, RR 0.58, p = 0.049, treatment 17 of 178 (9.6%), control 27 of 221 (12.2%), odds ratio converted to relative risk, multivariate logistic regression.
risk of IgG+, 79.0% lower, RR 0.21, p = 0.09, treatment 1 of 39 (2.6%), control 27 of 221 (12.2%), NNT 10, HCQ >10 weeks.
risk of IgG+, 52.4% lower, RR 0.48, p = 0.14, treatment 5 of 86 (5.8%), control 27 of 221 (12.2%), NNT 16, HCQ 6-10 weeks.
risk of IgG+, 69.9% higher, RR 1.70, p = 0.12, treatment 11 of 53 (20.8%), control 27 of 221 (12.2%), HCQ <6 weeks.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Yadav et al., 9/30/2020, retrospective, India, South Asia, preprint, 11 authors.
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