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All Studies   Meta Analysis   Recent: 
Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture
Yuan et al., Communications Biology, doi:10.1038/s42003-022-03841-8 (In Vitro)
14 Sep 2022    Source   PDF   Share   Tweet
In Vitro study showing that HCQ blocks SARS-CoV-2 entry into the endocytic pathway, and that HCQ was more effective with higher cholesterol.
Authors also obtained lung samples from adults with chronic obstructive pulmonary disease, finding that lung tissue had significantly higher free-cholesterol levels compared to cultured lung cell lines; and noting that animal and cultured-cell experiments in low cholesterol likely fail to capture the full benefits of HCQ.
Authors note that omicron has been shown to enter primarily through the endocytic pathway. [Delandre] also predict better efficacy of CQ with omicron compared to most previous variants.
Yuan et al., 14 Sep 2022, peer-reviewed, 10 authors.
Contact: shansen@scripps.edu.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
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