Impact of Azithromycin and/or Hydroxychloroquine on Hospital Mortality in COVID-19

Albani et al., J, Clinical Medicine, doi:10.3390/jcm9092800 (Peer Reviewed)
Impact of Azithromycin and/or Hydroxychloroquine on Hospital Mortality in COVID-19

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Retrospective 1376 hospitalized patients in Italy, 211 treated with HCQ and 166 with HCQ+AZ.

Albani et al., 8/30/2020, retrospective, Italy, Europe, peer-reviewed, 11 authors.

risk of death, 18.4% lower, RR 0.82, p = 0.05, treatment 60 of 211 (28.4%), control 172 of 605 (28.4%), adjusted per study, odds ratio converted to relative risk, HCQ vs. neither.

risk of death, 9.0% higher, RR 1.09, p = 0.38, treatment 60 of 211 (28.4%), control 172 of 605 (28.4%), adjusted per study, odds ratio converted to relative risk, HCQ+AZ vs. neither.

risk of ICU admission, 9.2% higher, RR 1.09, p = 0.68, treatment 73 of 211 (34.6%), control 46 of 605 (7.6%), adjusted per study, odds ratio converted to relative risk, HCQ vs. neither.

risk of ICU admission, 71.3% higher, RR 1.71, p < 0.001, treatment 73 of 211 (34.6%), control 46 of 605 (7.6%), adjusted per study, odds ratio converted to relative risk, HCQ+AZ vs. neither.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

All 320 studies Meta Analysis

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