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0 0.5 1 1.5 2+ Mortality 18% Improvement Relative Risk Mortality (b) -9% ICU admission -9% ICU admission (b) -71% c19hcq.com Albani et al. HCQ for COVID-19 LATE TREATMENT Favors HCQ Favors control
Albani, 816 patient HCQ late treatment study: 18% lower mortality [p=0.15] and 9% higher ICU admission [p=0.7] https://c19p.org/albani
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Impact of Azithromycin and/or Hydroxychloroquine on Hospital Mortality in COVID-19
Albani et al., J, Clinical Medicine, doi:10.3390/jcm9092800
30 Aug 2020    Source   PDF   Share   Tweet
Retrospective 1376 hospitalized patients in Italy, 211 treated with HCQ and 166 with HCQ+AZ.
risk of death, 18.4% lower, RR 0.82, p = 0.15, treatment 60 of 211 (28.4%), control 172 of 605 (28.4%), adjusted per study, odds ratio converted to relative risk, HCQ vs. neither.
risk of death, 9.0% higher, RR 1.09, p = 0.54, treatment 60 of 211 (28.4%), control 172 of 605 (28.4%), adjusted per study, odds ratio converted to relative risk, HCQ+AZ vs. neither.
risk of ICU admission, 9.2% higher, RR 1.09, p = 0.70, treatment 73 of 211 (34.6%), control 46 of 605 (7.6%), adjusted per study, odds ratio converted to relative risk, HCQ vs. neither.
risk of ICU admission, 71.3% higher, RR 1.71, p < 0.001, treatment 73 of 211 (34.6%), control 46 of 605 (7.6%), adjusted per study, odds ratio converted to relative risk, HCQ+AZ vs. neither.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: substantial unadjusted confounding by indication likely, substantial confounding by time likely due to declining usage over the early stages of the pandemic when overall treatment protocols improved dramatically.
Albani et al., 8/30/2020, retrospective, Italy, Europe, peer-reviewed, 11 authors.
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Late treatment
is less effective
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