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0 0.5 1 1.5 2+ Case 4% Improvement Relative Risk c19hcq.com Gendebien et al. HCQ for COVID-19 PrEP Favors HCQ Favors control
Gendebien, 225 patient HCQ prophylaxis study: 4% fewer cases [p=0.93] https://c19p.org/gendebien
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Systematic analysis of COVID-19 infection and symptoms in a systemic lupus erythematosus population: correlation with disease characteristics, hydroxychloroquine use and immunosuppressive treatments
Gendebien et al., Annals of the Rheumatic Diseases, doi:10.1136/annrheumdis-2020-218244 (Letter)
25 Jun 2020    Source   PDF   Share   Tweet
Small study of 152 SLE patients taking HCQ with a phone survey for COVID-19 suggestive symptoms. There was 2 hospitalizations (group not identified) and no ICU or death cases. A similar percentage of suspected infections were reported for HCQ users and non-HCQ users, RR 0.96, p = 0.93.
There was no mortality and severity was not analyzed to determine if HCQ treated patients fared better. No adjustment for concomitant medications or severity of SLE. Only 5 cases were PCR confirmed.
risk of case, 3.9% lower, RR 0.96, p = 0.93, treatment 12 of 152 (7.9%), control 6 of 73 (8.2%), NNT 308.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: not fully adjusting for the baseline risk differences within systemic autoimmune patients.
Gendebien et al., 6/25/2020, retrospective, Belgium, Europe, preprint, survey, 9 authors.
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