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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 50% Improvement Relative Risk Mortality (b) 51% Mortality (c) -8% Mechanical ventilation 48% ICU admission 12% Hospitalization 1% c19vitamind.com/jimenez.html Favors vitamin D Favors control
26 July 2021 - Prophylaxis study
Mortality in Hemodialysis Patients with COVID-19, the Effect of Paricalcitol or Calcimimetics
Jimenez et al., Nutrients, doi:10.3390/nu13082559 (Peer Reviewed)
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Retrospective 288 hemodialysis patients in Spain, 137 with existing vitamin D treatments (94 with paricalcitol), showing lower mortality with treatment. There was no significant difference in outcomes based on serum levels, however authors do not separate patients that received vitamin D treatment.
risk of death, 50.1% lower, RR 0.50, p = 0.02, treatment 16 of 94 (17.0%), control 65 of 191 (34.0%), NNT 5.9, adjusted per study, paricalcitol treatment, multivariate Cox regression.
risk of death, 50.7% lower, RR 0.49, p = 0.003, all vitamin D derivatives, univariate.
risk of death, 7.7% higher, RR 1.08, p = 0.81, high D levels 50, low D levels 110, >30 vs. <20ng/ml, RR approximated with OR, excluded in exclusion analyses: many patients received vitamin D treatment.
risk of mechanical ventilation, 47.5% lower, RR 0.53, p = 0.56, high D levels 50, low D levels 110, >30 vs. <20ng/ml, RR approximated with OR, excluded in exclusion analyses: many patients received vitamin D treatment.
risk of ICU admission, 12.2% lower, RR 0.88, p = 0.87, high D levels 50, low D levels 110, >30 vs. <20ng/ml, RR approximated with OR, excluded in exclusion analyses: many patients received vitamin D treatment.
risk of hospitalization, 0.8% lower, RR 0.99, p = 0.98, high D levels 50, low D levels 110, >30 vs. <20ng/ml, RR approximated with OR, excluded in exclusion analyses: many patients received vitamin D treatment.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Jimenez et al., 7/26/2021, retrospective, Spain, Europe, peer-reviewed, 21 authors, study period 12 March, 2020 - 21 May, 2020, dosage paricalcitol 0.9μg weekly.
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