7 January 2022 - Pre-Exposure Prophylaxis study (treated before exposed to the virus)
Hydroxychloroquine pre-exposure prophylaxis provides no protection against COVID-19 among health care workers: a cross-sectional study in a tertiary care hospital in North India
et al., Journal of Basic and Clinical Physiology and Pharmacology,
Retrospective 2,200 healthcare workers in India, 996 taking HCQ prophylaxis, showing no significant differences. There were large differences in the occupation of participants and therefore exposure, and the authors make no adjustments.
risk of severe case, 141.8% higher, RR 2.42, p = 0.59, treatment 2 of 996 (0.2%), control 1 of 1,204 (0.1%).
risk of case, 6.4% higher, RR 1.06, p = 0.67, treatment 103 of 996 (10.3%), control 117 of 1,204 (9.7%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
This study is excluded in the after exclusion results of meta
excessive unadjusted differences between groups.
Juneja et al., 1/7/2022, retrospective, India, South Asia, peer-reviewed, 9 authors, study period 2 April, 2020 - 3 September, 2020.