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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Case 9% Improvement Relative Risk Case (b) 12% c19vitamind.com/li6.html Favors vitamin D Favors control
19 May 2021 - Analysis of outcomes based on serum levels
Assessment of the Association of Vitamin D Level With SARS-CoV-2 Seropositivity Among Working-Age Adults
Li et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2021.11634 (Peer Reviewed)
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Cohort study of 18,148 patients in the USA showing low vitamin D associated with COVID-19 PCR+ status before adjustments but not after.
Authors state that "low vitamin D levels were not independently associated with the
risk of seropositivity", however there is significant correlation between some adjustment variables and vitamin D levels in the logistic regression that prevent drawing this conclusion [1]. Details of the logistic regression in the matched sample set are not provided.
Authors analyze only 20ng/mL and 30ng/mL cutoff points, other studies use 10ng/mL (or 12), where more significant differences are typically seen.
risk of case, 8.6% lower, RR 0.91, p = 0.24, high D levels 610 of 13,650 (4.5%), low D levels 290 of 4,498 (6.4%), NNT 51, adjusted per study, odds ratio converted to relative risk, >20ng/mL, Figure 2.
risk of case, 12.4% lower, RR 0.88, p = 0.07, high D levels 289 of 7,272 (4.0%), low D levels 611 of 10,876 (5.6%), NNT 61, adjusted per study, odds ratio converted to relative risk, >30ng/mL, Figure 2.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Li et al., 5/19/2021, retrospective, USA, North America, peer-reviewed, 4 authors.
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