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0 0.5 1 1.5 2+ Mortality -70% Improvement Relative Risk c19hcq.com McGrail et al. HCQ for COVID-19 LATE TREATMENT Favors HCQ Favors control
McGrail, 75 patient HCQ late treatment study: 70% higher mortality [p=0.69] https://c19p.org/mcgrail
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COVID-19 Case Series at UnityPoint Health St. Luke’s Hospital in Cedar Rapids, IA
McGrail et al., medRxiv, doi:10.1101/2020.07.17.20156521 (Preprint)
19 Jul 2020    Source   PDF   Share   Tweet
HCQ+AZ early in the epidemic had a fairly good success rate with few complications, 86% of HCQ patients survived and 92% of HCQ+AZ patients. Patients not receiving either had 93% survival but were not considered comparable because the treated groups were significantly more ill (100% hypoxic at admission vs. 59%) and this study does not adjust for the differences.
Transition from an early intubation strategy to aggressive utilization of high flow nasal cannula and noninvasive ventilation (i.e, BiPAP) was successful in freeing up ICU resources.
risk of death, 70.0% higher, RR 1.70, p = 0.69, treatment 4 of 33 (12.1%), control 3 of 42 (7.1%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: excessive unadjusted differences between groups.
McGrail et al., 7/19/2020, retrospective, USA, North America, preprint, 2 authors.
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Late treatment
is less effective
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