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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality -45% Improvement Relative Risk c19hcq.com/sarfaraz.html Favors HCQ Favors control
2 January 2021 - Late treatment study
Determinants of in-hospital mortality in COVID-19; a prospective cohort study from Pakistan
Sarfaraz et al., medRxiv, doi:10.1101/2020.12.28.20248920 (Preprint)
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Retrospective 186 hospitalized patients in Pakistan showing unadjusted HCQ mortality RR 1.45, p = 0.07. Confounding by indication is likely.
risk of death, 45.0% higher, RR 1.45, p = 0.07, treatment 40 of 94 (42.6%), control 27 of 92 (29.3%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
This study is excluded in the after exclusion results of meta analysis: substantial unadjusted confounding by indication likely, significant unadjusted confounding possible, unadjusted results with no group details.
Sarfaraz et al., 1/2/2021, retrospective, Pakistan, South Asia, preprint, 7 authors, average treatment delay 7.0 days.
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