Retrospective 40 pediatric hospitalized patients, 15 treated with HCQ, showing 7.2 vs. 8.2 days until PCR-, not quite reaching statistical significance.
Uygen et al., 9/15/2021, retrospective, Turkey, Europe, peer-reviewed, 4 authors.
time to viral-, 12.2% lower, relative time 0.88, p = 0.05, treatment 15, control 25.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.