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0 0.5 1 1.5 2+ Mortality 65% Improvement Relative Risk Mortality (b) -376% Viral clearance -3% c19hcq.com Hraiech et al. HCQ for COVID-19 ICU PATIENTS Favors HCQ Favors control
Hraiech, 32 patient HCQ ICU study: 65% lower mortality [p=0.21] and 3% worse viral clearance [p=1] https://c19p.org/hraiech
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Lack of viral clearance by the combination of hydroxychloroquine and azithromycin or lopinavir and ritonavir in SARS-CoV-2-related acute respiratory distress syndrome
Hraiech et al., Ann. Intensive Care, doi:10.1186/s13613-020-00678-4
24 May 2020    Source   PDF   Share   Tweet
Retrospective 45 ICU patients, 17 treated with HCQ+AZ, showing no significant difference in viral clearance after 6 days, or mortality 6 days from ARDS.
risk of death, 64.7% lower, RR 0.35, p = 0.21, treatment 2 of 17 (11.8%), control 5 of 15 (33.3%), NNT 4.6, day 38 +- 7.
risk of death, 376.5% higher, RR 4.76, p = 0.49, treatment 2 of 17 (11.8%), control 0 of 15 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), day 6 from ARDS.
risk of no viral clearance, 2.9% higher, RR 1.03, p = 1.00, treatment 14 of 17 (82.4%), control 8 of 10 (80.0%), day 6 from treatment.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: very late stage, ICU patients.
Hraiech et al., 5/24/2020, retrospective, France, Europe, peer-reviewed, 8 authors, average treatment delay 7.0 days.
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