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HCQ study #362   Meta Analysis
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 26% Imp. Relative Risk, 95% CI Hospital discharge 26% Hospitalization time -25% Sarhan: Efficacy of the early treatment with tocilizumab-hydroxy.. c19hcq.com/sarhan.html Favors HCQ Favors control
11/2 Late treatment study
Sarhan et al., Journal of Infection and Public Health, doi:10.1016/j.jiph.2021.10.024 (Peer Reviewed)
Efficacy of the early treatment with tocilizumab-hydroxychloroquine and tocilizumab-remdesivir in severe COVID-19 Patients
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Small 108 patient RCT comparing HCQ vs. remdesivir in very late stage treatment. All patients received tocilizumab. There were significant unadjusted baseline differences in ventilation and ICU admission. NCT04779047. REC-H-PhBSU-21011.
risk of death, 25.7% lower, RR 0.74, p = 0.39, treatment 12 of 56 (21.4%), control 15 of 52 (28.8%).
risk of no hospital discharge, 25.7% lower, RR 0.74, p = 0.39, treatment 12 of 56 (21.4%), control 15 of 52 (28.8%).
hospitalization time, 25.0% higher, relative time 1.25, p = 0.06, treatment 56, control 52.
This study is excluded in the after exclusion results of meta analysis: very late stage, >50% on oxygen/ventilation at baseline, significant unadjusted differences between groups.
Sarhan et al., 11/2/2021, Randomized Controlled Trial, Egypt, Africa, peer-reviewed, 8 authors, this trial compares with another treatment - results may be better when compared to placebo.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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