Sarhan: Efficacy of the early treatment with tocilizumab-hydroxychloroquine and tocilizumab-remdesivir in severe COVID-19 Patients

Sarhan, 108 patient HCQ late treatment RCT: 26% lower mortality [p=0.39], 26% higher hospital discharge [p=0.39], and 25% longer hospitalization [p=0.06] https://c19p.org/sarhan

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Efficacy of the early treatment with tocilizumab-hydroxychloroquine and tocilizumab-remdesivir in severe COVID-19 Patients

Sarhan et al., Journal of Infection and Public Health, doi:10.1016/j.jiph.2021.10.024, NCT04779047 (history)

2 Nov 2021 Source PDF Share Tweet

Small 108 patient RCT comparing HCQ vs. remdesivir in very late stage treatment. All patients received tocilizumab. There were significant unadjusted baseline differences in ventilation and ICU admission. NCT04779047 (history). REC-H-PhBSU-21011.

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risk of death, 25.7% lower, RR 0.74, p = 0.39, treatment 12 of 56 (21.4%), control 15 of 52 (28.8%), NNT 13.

risk of no hospital discharge, 25.7% lower, RR 0.74, p = 0.39, treatment 12 of 56 (21.4%), control 15 of 52 (28.8%), NNT 13.

hospitalization time, 25.0% higher, relative time 1.25, p = 0.06, treatment 56, control 52.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

This study is excluded in the after exclusion results of meta analysis: very late stage, >50% on oxygen/ventilation at baseline, significant unadjusted differences between groups.

Sarhan et al., 2 Nov 2021, Randomized Controlled Trial, Egypt, peer-reviewed, 8 authors, study period 1 October, 2020 - 10 March, 2021, this trial compares with another treatment - results may be better when compared to placebo, trial NCT04779047 (history).

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This Paper HCQ All

Late treatment
is less effective

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