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0 0.5 1 1.5 2+ Mortality 58% Improvement Relative Risk Ventilation 74% ICU admission 70% c19hcq.com Tsanovska et al. HCQ for COVID-19 LATE TREATMENT Favors HCQ Favors control
Tsanovska, 140 patient HCQ late treatment PSM study: 58% lower mortality [p=0.03], 74% lower ventilation [p=0.0007], and 70% lower ICU admission [p=0.0004] https://c19p.org/tsanovska
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Hydroxychloroquine (HCQ) treatment for hospitalized patients with COVID- 19.
Tsanovska et al., Infectious Disorders - Drug Targets, doi:10.2174/1871526522666220303121209
3 Mar 2022    Source   PDF   Share   Tweet
PSM prospective study of 260 COVID-19 patients in Bulgaria, showing lower mortality, ventilation, and ICU admission with HCQ treatment.
risk of death, 57.9% lower, RR 0.42, p = 0.03, treatment 8 of 70 (11.4%), control 19 of 70 (27.1%), NNT 6.4, propensity score matching.
risk of mechanical ventilation, 73.9% lower, RR 0.26, p < 0.001, treatment 6 of 70 (8.6%), control 23 of 70 (32.9%), NNT 4.1, propensity score matching.
risk of ICU admission, 70.4% lower, RR 0.30, p < 0.001, treatment 8 of 70 (11.4%), control 27 of 70 (38.6%), NNT 3.7, propensity score matching.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Tsanovska et al., 3/3/2022, prospective, Bulgaria, Europe, peer-reviewed, 8 authors, study period 6 November, 2020 - 28 December, 2020.
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Late treatment
is less effective
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