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0 0.5 1 1.5 2+ Mortality -44% Improvement Relative Risk c19hcq.com Arabi et al. NCT02735707 REMAP-CAP HCQ RCT ICU PATIENTS Favors HCQ Favors control
Arabi, 402 patient HCQ ICU RCT: 44% higher mortality [p=0.01] https://c19p.org/arabi
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Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial
Arabi et al., Intensive Care Medicine, REMAP-CAP, NCT02735707 (history)
12 Jul 2021    Source   PDF   Share   Tweet
Very late stage RCT with 50 ICU patients treated with HCQ, 255 lopinavir-ritonavir patients, and 27 combined therapy patients, showing higher mortality with all treatments.
risk of death, 44.5% higher, RR 1.44, p = 0.01, treatment 17 of 49 (34.7%), control 106 of 353 (30.0%), adjusted per study, inverted to make RR<1 favor treatment, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Arabi et al., 12 Jul 2021, Randomized Controlled Trial, multiple countries, peer-reviewed, 1 author, trial NCT02735707 (history) (REMAP-CAP).
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This PaperHCQAll
Late treatment
is less effective
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