Retrospective 188 hospitalized patients in Brazil, showing higher risk of mortality with HCQ. Relatively few patients received HCQ. The results are likely subject to
confounding by indication with treatment more likely for severe cases, and severity was not used in adjustments.
Confounding by time is likely, with declining use of HCQ and improving SOC over the study period.
risk of death, 299.0% higher, OR 3.99, p = 0.04, treatment 25, control 163, adjusted per study, multivariable, RR approximated with OR.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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This study is excluded in the after exclusion results of meta
analysis:
substantial unadjusted
confounding by indication likely, substantial
confounding by time likely due to declining usage over the early stages of the pandemic when overall treatment protocols improved dramatically.
Tamura et al., 7/13/2021, retrospective, Brazil, South America, peer-reviewed, 4 authors, study period 10 March, 2020 - 13 November, 2020.