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0 0.5 1 1.5 2+ Mortality -299% Improvement Relative Risk c19hcq.com Tamura et al. HCQ for COVID-19 LATE TREATMENT Favors HCQ Favors control
Tamura, 188 patient HCQ late treatment study: 299% higher mortality [p=0.04] https://c19p.org/tamurah
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Outcome and death risk of diabetes patients with Covid-19 receiving pre-hospital and in-hospital metformin therapies
Tamura et al., Diabetology & Metabolic Syndrome, doi:10.1186/s13098-021-00695-8
13 Jul 2021    Source   PDF   Share   Tweet
Retrospective 188 hospitalized patients in Brazil, showing higher risk of mortality with HCQ. Relatively few patients received HCQ. The results are likely subject to confounding by indication with treatment more likely for severe cases, and severity was not used in adjustments. Confounding by time is likely, with declining use of HCQ and improving SOC over the study period.
risk of death, 299.0% higher, OR 3.99, p = 0.04, treatment 25, control 163, adjusted per study, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: substantial unadjusted confounding by indication likely, substantial confounding by time likely due to declining usage over the early stages of the pandemic when overall treatment protocols improved dramatically.
Tamura et al., 13 Jul 2021, retrospective, Brazil, peer-reviewed, 4 authors, study period 10 March, 2020 - 13 November, 2020.
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